"Before you quit your job and sell the farm, you should have some idea of the direction you're heading in," says Lynn Avitabile, managing director, global head of HR for JPMorgan Global Asset Management. (JPMorgan Chase is No. 25 on The DiversityInc Top 50 Companies for Diversity list.) "If you're independently wealthy, it doesn't matter. But most people aren't in that situation. Some simply hate what they're doing and aspire to do something different. The key is trying to figure out